Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2146752 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2010 | 8 Pages |
Abstract
Fpg protein from Escherichia coli belongs to the class of DNA glycosylases/abasic site lyases excising several oxidatively damaged purines in the base excision repair pathway. In this review, we summarize the results of our studies of Fpg protein from E. coli, elucidating the intrinsic mechanism of recognition and excision of damaged bases in DNA.
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Authors
Vladimir V. Koval, Nikita A. Kuznetsov, Alexander A. Ishchenko, Murat K. Saparbaev, Olga S. Fedorova,