| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2147111 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2008 | 7 Pages |
Abstract
Embryonic stem cells (ESCs) are characterized by their broad developmental potential and the capacity to self-renew. The advent of high-throughput technologies has facilitated genome-wide studies of transcriptional network, resulting in an ever-increasing repertoire of transcription factors implicated in the maintenance of the embryonic stem cell state. While the transcriptional circuitry continues to expand, epigenetic regulation has also gained attention as an important process in stem cell function. Herein, we discuss the recent advancements made in understanding the transcriptional and epigenetic regulations of embryonic stem cells.
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Authors
Jia-Hui Ng, Jian-Chien Dominic Heng, Yuin-Han Loh, Huck-Hui Ng,