Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2147537 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2006 | 4 Pages |
Abstract
Genetic variation inferred from large-scale amino acid composition comparisons among genomes and chromosomes of several species, Saccharomyces cerevisiae, Drosophila melanogaster, Ceanorhabditis elegans, H. sapiens, is shown to be correlated (highest, r2 = 0.9855, p < 0.01) with reported mutation rates for various genes in these species. This study, based largely on pseudogene data, helps to establish reference mutation frequencies that are likely to be representative of overall genome mutation rates in each of the species examined, and provides further insight into heterogeneity of mutation rates among genomes.
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Authors
Amandio Vieira,