Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2147560 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2006 | 9 Pages |
Abstract
Aberrant crypt foci (ACF) are the earliest identifiable neoplastic lesions in the colon. Thirty-two ACFs were examined for genomic instability in forms detectable either by inter-(simple sequence repeat) PCR or by array comparative genomic hybridization [array-CGH]. One-fourth of ACFs revealed moderate instability by inter-(simple sequence repeat) PCR; none showed amplifications or deletions on array-CGH. The absence of genomic events detectible by BAC array-CGH indicates early events in colorectal tumor progression are typically smaller than the approximate 150 kb size of a BAC clone insert.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Sadir J. Alrawi, Robert E. Carroll, Hank C. Hill, John F. Gibbs, Dongfeng Tan, Bruce M. Brenner, Norma J. Nowak, Helen Swede, Daniel L. Stoler, Garth R. Anderson,