Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2147673 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2006 | 5 Pages |
Abstract
The catechins in green tea have antioxidative and antimutagenic effects. We examined the effect of green tea enriched with catechins on the presence of mitochondrial DNA (mtDNA) with a common 4977-bp deletion mutation (mtDNA4977) in human leucocytes.Ten healthy females [aged 20.80 ± 1.03 years] drank 350 ml of catechin-rich tea daily after supper for 5 weeks. Blood samples were collected twice before, and twice after 5 weeks of consuming the tea. Deletions in mtDNA were analyzed using the nested polymerase chain reaction (PCR).We identified a common mtDNA4977 deletion in nine participants before drinking the tea. However, this mtDNA4977 deletion was not evident in leucocytes from most of t
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Authors
Koichi Iwai, Yukio Iwamura, Shuhei Yamashita, Yasuyoshi Wadano, Noboru Mesaki,