| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2148093 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2013 | 10 Pages |
•Almost half cases of PLC in the present series are considered as cryptogenic.•Most cases arose from non-cirrhotic livers.•At variance with European cases, CTNNB1 mutation was rare.•Aflatoxin-related mutation of TP53 was absent in Russian PLC.•Loss of certain chromosomes (e.g. 18q) depends on the regional origin of patients.
Primary liver cancer (PLC) is a major public health concern worldwide, ranking third among the causes of death from cancer. Molecular pathogenesis of PLC is known to be especially sensitive to ethno-environmental variations that modulate mutation spectra in tumours. Despite a high prevalence of chronic liver diseases, the molecular epidemiology of PLC is still poorly known in Russia. To characterize the major genetic features of liver tumours in Russian populations, we conducted a pilot study on 34 PLC cases (28 hepatocellular, two cholangiocellular, and four mixed cases) among patients attending the Radiology and Roentgenology Hospital in
