| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2148390 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2010 | 7 Pages |
The acute toxicity, genotoxicity, and cytotoxicity of the pirimicarb-containing commercial-formulation carbamate insecticide Aficida® (50% pirimicarb) were evaluated on Cnesterodon decemmaculatus (Pisces, Poeciliidae) exposed under laboratory conditions. Micronucleus (MN) induction as well as alterations in the erythrocytes:erythroblasts ratios were employed as end-points for genotoxicity and cytotoxicity, respectively. Cr(VI) and cyclophosphamide were used as positive controls for the toxicity and geno-cytotoxicity assays, respectively. Mean values of 344.3 and 225.5 mg Aficida®/L were determined for LC-5024 h and LC-5096 h, respectively. In 48 h-exposed fish, a MN increase was found in Aficida®-treated fish in the 50–157 mg/L concentration range. When fish were exposed to Aficida® for 96 h, only those animals treated at 50–100 mg/L showed an increase in MN frequency. Cellular cytotoxicity, revealed by a decreased proportion of circulating erythrocytes and an enhancement of erythroblasts, was found after 48 h of exposure in 50–157 mg Aficida®/L-treated fish, while, after 96 h exposure, only 100–157 mg Aficida®/L induced the same effect. This species provides a useful experimental model for the biomonitoring of aquatic ecosystems.
