| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2148399 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2011 | 8 Pages |
Abstract
ⶠPhenylalanine 171 is inhibitory for translesion bypass by human DNA polymerase kappa. ⶠThe change of the amino acid to alanine enhanced translesion efficiency. ⶠThe derivative passed benzo[a]pyrene adducts in DNA about 20 times more efficiently. ⶠThe finding raises a question of why it has a molecular brake for error-free bypass.
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![Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa](/preview/png/2148399.png "First Page Preview: Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa")
Authors
Akira Sassa, Naoko Niimi, Hirofumi Fujimoto, Atsushi Katafuchi, Petr Grúz, Manabu Yasui, Ramesh C. Gupta, Francis Johnson, Toshihiro Ohta, Takehiko Nohmi,