| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2148427 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2010 | 9 Pages |
Abstract
We study the mechanisms that in mammalian cells keep the dNTP pools in balance, and are particularly interested in the enzymes that, similar to thymidine phosphorylase, contribute to pool regulation by degrading dNTP precursors. The role of some relevant enzymes is illustrated with data obtained by chemical or genetic manipulation of their expression in cultured mammalian cells.
Keywords
dCKMDNdNMPdeoxyadenosineCDNPMOLTK2ssDNANDPADRDGKdNTPDeoxyuridineTK1CNIPNPGDRTDRpicomoleCPMUDRNTPdNDPSingle-stranded DNAadenosine deaminaseThymidineThymidine phosphorylasemitochondrial thymidine kinasedeoxynucleoside triphosphatedeoxycytidine kinaseDeoxyguanosine kinaseDeoxyguanosinemtDNAribonucleoside triphosphatecounts per minuteNucleoside phosphorylasesMitochondrialknockoutADAPurine nucleoside phosphorylase
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Authors
Chiara Rampazzo, Cristina Miazzi, Elisa Franzolin, Giovanna Pontarin, Paola Ferraro, Miriam Frangini, Peter Reichard, Vera Bianchi,