| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2148649 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2009 | 7 Pages |
Abstract
Genotoxic effects of traffic-generated particulate matter (PM) are well described, whereas little data are available on PM from combustion of biomass and wood, which contributes substantially to air pollution world wide. The aim of this study was to compare the genotoxicity of wood smoke particulate matter (WSPM), authentic traffic-generated particles, mineral PM and standard reference material (SRM2975) of diesel exhaust particles in human A549 lung epithelial and THP-1 monocytic cell lines. DNA damage was measured as strand breaks (SB) and formamidopyrimidine DNA glycosylase (FPG) sites by the comet assay, whereas cell cytotoxicity was determined as lactate dehydrogenase r
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Authors
Pernille Høgh Danielsen, Steffen Loft, Anette Kocbach, Per E. Schwarze, Peter Møller,