Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2148754 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2009 | 18 Pages |
Abstract
Implementation of the Vitotox⢠and RadarScreen assays in the early research phase of drug development can lead to fast de-selection for genotoxicity. It is expected that this application will reduce the number of compounds that have a positive score in the regulatory Ames and clastogenicity tests. Moreover, problems with a complete compound class can be foreseen at an early time point in the research phase, which gives more time for issue resolution than late detection of these problems with the regulatory tests.
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Authors
Walter M.A. Westerink, Joe C.R. Stevenson, Annick Lauwers, Gerard Griffioen, G. Jean Horbach, Willem G.E.J. Schoonen,