Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2149032 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2008 | 5 Pages |
Abstract
Zero-valent nickel compounds are organometallic chemicals that are used in synthetic applications and may also occur as intermediates in nickel-catalyzed hydrogenation reactions used in food processing. Few studies have been performed on their possible genotoxic actions. We have tested two commercially available examples of this class of compounds. Solubility and stability were examined. Mutagenicity testing did not confirm a previous report that bis(1,5-cyclooctadiene)nickel is positive in the Ames assay. No stimulation of lipid peroxidation was observed in studies of bovine erythrocytes exposed in vitro. Our results do not indicate that zero-valent nickel compounds have genotoxic effects.
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Authors
P. David Josephy, Jody J. Weadge, Joseph Meissner, Filomena Ng,