Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2149384 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2006 | 10 Pages |
Abstract
The comet tail lengths of epidermal cells of the mice were statistically significantly increased for all three fluoroquinolones (FQ) tested in combination with UV irradiation. Treatment with 8-methoxypsoralene + UV induced a significant reduction of comet tail length. Tail intensity and tail moment gave essentially the same results after combined exposure (compound + UV). Without irradiation, the tail lengths of controls and compound-treated mice were comparable under the conditions of this study. In contrast, tail intensity and tail moment were increased for all test compounds (including 8-MOP), without irradiation. Irradiated controls had a tail length comparable to non-irradiated controls, while tail intensity and tail moment were clearly increased in irradiated controls. In conclusion: under the present experimental conditions the in vivo photo-comet assay is able to detect photo-chemically induced DNA strand breaks as well as photo-chemically induced DNA cross-links.
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Authors
Uta Wirnitzer, Nicole Gross-Tholl, Bernd Herbold, Eckhard von Keutz,