Thermodynamic properties of peptide solutions 20. Partial molar volumes and isothermal compressions for some tripeptides of sequence gly-X-gly (X = gly, ala, leu, asn, thr, and tyr) in aqueous solution at T = 298.15 K and p = (10–120) MPa

•Sound speeds were measured for aqueous solutions of some tripeptides at high pressures.•Partial molar volumes and isothermal compressions were derived for T = 298.15 K and p = (10–120) MPa.•The partial molar volumes for non-polar amino acid side-chains decrease with increasing pressure.•The partial molar volumes for polar side-chains do not change significantly with increasing pressure.

Sound speeds have been measured for aqueous solutions of six tripeptides of sequence glycyl-X-glycine, where X is one of the amino acids glycine, alanine, leucine, asparagine, threonine, and tyrosine at T = 298.15 K and at the pressures p = (10, 20, 40, 60, 80, 100, and 120) MPa. Using methods described in previous work, these sound speeds were used to derive the partial molar volumes at infinite dilution, V2o, the partial molar isentropic compressions at infinite dilution, KS,2o, and the partial molar isothermal compressions at infinite dilution, KoT,2 {KoT,2 = −(∂V2o/∂p)T}, for the tripeptides in aqueous solution at the elevated pressures. The results were used to calculate the partial molar volumes and partial molar isothermal compressions for the various amino acid side-chains over the pressure range p = (10–120) MPa.

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