Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2152463 | Neoplasia | 2007 | 11 Pages |
Abstract
BACKGROUND: Carcinoma of the prostate (CaP) is the most commonly diagnosed cancer in men in the United States. Signal transduction molecules such as tyrosine kinases play important roles in CaP. Src, a nonreceptor tyrosine kinase (NRTK) and the first proto-oncogene discovered is shown to participate in processes such as cell proliferation and migration in CaP. Underscoring NRTK's and, specifically, Src's importance in cancer is the recent approval by the US Food and Drug Administration of dasatinib, the first commercial Src inhibitor for clinical use in chronic myelogenous leukemia (CML). In this review we will focus on NRTKs and their roles in the biology of CaP. MATERIALS AND METHODS: Publicly available literature from PubMed regarding the topic of members of NRTKs in CaP was searched and reviewed. RESULTS: Src, FAK, JaK1/2, and ETK are involved in processes indispensable to the biology of CaP: cell growth, migration, invasion, angiogenesis, and apoptosis. CONCLUSIONS: Src emerges as a common signaling and regulatory molecule in multiple biological processes in CaP. Src's relative importance in particular stages of CaP, however, required further definition. Continued investigation of NRTKs will increase our understanding of their biological function and potential role as new therapeutic targets.
Keywords
LCKRASSRCCMLABLIGF-1HIF-1αPKCLPAPDGFPAK1Tyk2TGFCSKKAI1/CD82CRKIIEt1TNKC-terminal Src kinaseNRTKnonreceptor tyrosine kinasemet proto-oncogene (hepatocyte growth factor receptor)v-raf-1 murine leukemia viral oncogene homolog 1FGRBCREGFMMPPSAPI3KFAKTECJanus kinaseERK1/2p130Casv-akt murine thymoma viral oncogene homolog 1STATETKArglysophosphatidic acidFERendothelinNeutral endopeptidaseinterleukinYESSyktyrosine kinase 2TIMPProstate cancerCarcinoma of the prostatespleen tyrosine kinaseepidermal growth factortumor growth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factorinsulin-like growth factor 1phosphatase and tensin homologPhosphatidylinositol 3-kinaseFynLynchronic myelogenous leukemiamatrix metalloproteinaseMETbreakpoint cluster regionTissue inhibitor of metalloproteinaseRatNEPSrc homologybenign prostatic hypertrophyBPHprostate-specific antigenlymphocyte-specific protein tyrosine kinaseProtein kinase CJAKBRCA1Ptenbreast cancer susceptibility gene 1CaPAIDextracellular signal-regulated kinase 1/2focal adhesion kinaseAndrogen ReceptorEstrogen receptor
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Authors
Cancer Yu-Ming Chang, Hsing-Jien Kung, Christopher P. Evans,