Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2153957 | Nuclear Medicine and Biology | 2013 | 8 Pages |
Abstract
[68Ga]Oxo-DO3A-RGD and [68Ga]NS3-RGD have inferior characteristics compared to already existing 68Ga-labeled RGD peptides and thus, both are not suited to image αvβ3 integrin expression. Of all our tested RGD peptides, [68Ga]NODAGA-RGD still possesses the most favorable imaging properties. Moreover this study shows that the use of appropriate chelators to achieve good targeting properties of 68Ga-labeled biomolecules and careful in vitro and in vivo evaluation including comparative studies of different strategies are essential components in designing an effective imaging agent for PET.
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Authors
Peter A. Knetsch, Milos Petrik, Christine Rangger, Gesine Seidel, Hans-Jürgen Pietzsch, Irene Virgolini, Clemens Decristoforo, Roland Haubner,