| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2154276 | Nuclear Medicine and Biology | 2011 | 15 Pages |
Abstract
These data suggest that D3 selective conformationally-flexible benzamide analogs which contain a N-2-methoxyphenylpiperazine moiety are substrates for P-glycoprotein or other adenosine triphosphate (ATP)-binding cassette transporters expressed at the blood-brain barrier, and that PET radiotracers containing this pharmacophore may display low brain uptake in rodents due to the action of these efflux transporters.
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Authors
Zhude Tu, Shihong Li, Jinbin Xu, Wenhua Chu, Lynne A. Jones, Robert R. Luedtke, Robert H. Mach,