Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2154331 | Nuclear Medicine and Biology | 2011 | 8 Pages |
Abstract
In this work, we report on a synthetic strategy using amphiphilic DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-based chelators bearing a variable-sized α-alkyl chain at one of the pendant acetate arms (from 6 to 14 carbon atoms), compatible with their covalent coupling to amine-bearing biomolecules. The amphiphilic behavior of the micelles-forming Ga(III) chelates (critical micellar concentration), their stability in blood serum and their lipophilicity (logP) were investigated. Biodistribution studies with the 67Ga-labeled chelates were performed in Wistar rats, which showed a predominant liver uptake with almost no traces of the radiochelates in the body after 24 h.
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Authors
André Fontes, M. Isabel M. Prata, Carlos F.G.C. Geraldes, João P. André,