| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2154451 | Nuclear Medicine and Biology | 2008 | 8 Pages |
Abstract
This study shows that celecoxib is not a substrate of Pgp and does not substantially affect the Pgp-mediated efflux of [11C]verapamil. Therefore, celecoxib-induced augmentation of the efficacy of chemotherapeutic and neurotropic drugs must be due to another mechanism than modulation of Pgp-mediated drug efflux.
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Authors
Erik F.J. de Vries, Janine Doorduin, Namkje A.R. Vellinga, Aren van Waarde, Rudi A. Dierckx, Hans C. Klein,