Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2154470 | Nuclear Medicine and Biology | 2008 | 7 Pages |
Abstract
To develop a potential SPECT probe to evaluate the integrity of the serotoninergic system (5-HTT) whose dysfunction is linked to several disease conditions such as Parkinson's disease, Alzheimer's disease and depression, we report the synthesis, radiolabeling and in vivo baboon imaging of 2β-carbomethoxy-3β-(3′-[123I]iodophenyl) tropane (YP256, 6). The radiolabeling was performed by iododestannylation using sodium [123I]iodide and peracetic acid. Although the ligand displayed high selectivity for 5-HTT over dopamine transporter in vitro, SPECT imaging in baboons did not reveal selective 5-HTT accumulation in brain in vivo.
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Authors
Frederic Bois, Ronald M. Baldwin, Louis Amici, Mohammed S. Al-Tikriti, Nora Kula, Ross Baldessarini, Robert B. Innis, Julie K. Staley, Gilles D. Tamagnan,