Article ID Journal Published Year Pages File Type
2154498 Nuclear Medicine and Biology 2010 10 Pages PDF
Abstract
The study confirmed the feasibility of cardiac SPECT reporter gene imaging with HSV1-tk as a reporter gene and 131I-FIAU as a reporter probe. The optimal Ad5-tk titer for imaging was 1×108 pfu and the optimal imaging time was 1-2 days after gene transfer. Thus, the imaging of HSV1-tk transgene expression in the heart is feasible and may be used for the noninvasive SPECT imaging of gene therapy in cardiac diseases.
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