Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2154498 | Nuclear Medicine and Biology | 2010 | 10 Pages |
Abstract
The study confirmed the feasibility of cardiac SPECT reporter gene imaging with HSV1-tk as a reporter gene and 131I-FIAU as a reporter probe. The optimal Ad5-tk titer for imaging was 1Ã108 pfu and the optimal imaging time was 1-2 days after gene transfer. Thus, the imaging of HSV1-tk transgene expression in the heart is feasible and may be used for the noninvasive SPECT imaging of gene therapy in cardiac diseases.
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Authors
Xiaoli Lan, Ying Liu, Yong He, Tao Wu, Binqing Zhang, Zairong Gao, Rui An, Yongxue Zhang,