Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2154864 | Nuclear Medicine and Biology | 2006 | 4 Pages |
Abstract
Tumor cells transduced with herpes simplex virus thymidine kinase gene has been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facial preparation of 5-[125I]iodoarabinosyl uridine starting from commercial available uridine is reported herein. Interestingly, the tin group in 5-trimethylstannyl arabinosyluridine was easily removed during purification. The destannylation through the formation of a six-ligand coordination involving 2â²-hydroxyl and tin was thereby proposed.
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Authors
Chung-Shan Yu, Li-Wu Chiang, Chien-Hung Wu, Ren-Tsong Wang, Shao-Wei Chen, Heng-Yen Wang, Chien-Hung Yeh,