Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2154910 | Nuclear Medicine and Biology | 2008 | 4 Pages |
IntroductionImaging of somatostatin receptor expressing tumours has been greatly enhanced by the use of 68Ga-DOTATOC and PET/CT.MethodsIn this work, a purification method for the 68Ge/68Ga generator eluate and a method to produce 68Ga-DOTATOC suitable for clinical use were evaluated. The generator eluate was purified and concentrated on a cation-exchange cartridge in HCl/acetone media. The efficacy of this procedure in eliminating metal impurities from the 68Ga solution was investigated by ICP-MS. The radiotracer quality was evaluated by radio-TLC, GC and γ-ray spectrometry.Results68Ga-DOTATOC preparations (n=33) were carried out with a mean synthesis yield of 59.3±2.8% (not corrected for decay) and a batch activity ranging from 555 to 296 MBq. The radiochemical and radionuclidic purity were >98% and 99.9999%, respectively. With this purification process, >95% of the Fe(III), Zn(II) and Mn(II) were eliminated from the solution.Conclusions68Ga-DOTATOC produced with this method can be efficiently used in nuclear medicine departments for PET evaluations.