Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2154928 | Nuclear Medicine and Biology | 2006 | 5 Pages |
Abstract
The present study focused on the preparation of novel bone tracers containing yttrium as radionuclide or carrier. Moreover, these preparations were comparatively evaluated in vitro on the basis of a recently presented pre vivo model comprising binding studies on synthetic and human bone powder. It was shown that among the therapeutic radionuclides, no carrier added [90Y]-EDTMP exceeded [188Re]-EDTMP while yielding lower binding values than [153Sm]-EDTMP. Furthermore, the authors investigated the influence of “foreign” carriers added to [90Y]-EDTMP, [99mTc]-EDTMP and [111In]-EDTMP by the method of cross-complexation. The findings reveal a new paradigm: a carrier more foreign to the complexed radionuclide causes a higher binding increase on human bone matrices in vitro than a more “related” carrier.
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Authors
Stefan Toegel, Leonhard-Key Mien, Wolfgang Wadsak, Harald Eidherr, Helmut Viernstein, Rainer Kluger, Dagmar Ettlinger, Kurt Kletter, Robert Dudczak, Markus Mitterhauser,