Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2154941 | Nuclear Medicine and Biology | 2007 | 12 Pages |
Abstract
Although xanomeline displays highly selective M1 agonist activity in functional assays, little selectivity for muscarinic subtype binding was observed for xanomeline or its fluorine-containing analogue, fluoroxanomeline. This emphasizes the lack of correlation between functional selectivity and binding selectivity.
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Authors
Dale O. Kiesewetter, Elaine M. Jagoda, Kazuaki Shimoji, Ying Ma, William C. Eckelman,