Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2154946 | Nuclear Medicine and Biology | 2007 | 9 Pages |
Abstract
Five novel dopamine D2/D3 agonists based on (+)-PHNO were synthesized and evaluated in vitro. F-PHNO was shown to behave as a potent D2 agonist in vitro and was therefore radiolabeled with fluorine-18. Despite the promising in vitro pharmacological profile, [18F]F-PHNO did not display in vivo behavior suitable to image dopaminergic receptor expression using PET.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Neil Vasdev, Philip Seeman, Armando Garcia, Winston T. Stableford, José N. Nobrega, Sylvain Houle, Alan A. Wilson,