Article ID Journal Published Year Pages File Type
2154946 Nuclear Medicine and Biology 2007 9 Pages PDF
Abstract
Five novel dopamine D2/D3 agonists based on (+)-PHNO were synthesized and evaluated in vitro. F-PHNO was shown to behave as a potent D2 agonist in vitro and was therefore radiolabeled with fluorine-18. Despite the promising in vitro pharmacological profile, [18F]F-PHNO did not display in vivo behavior suitable to image dopaminergic receptor expression using PET.
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