| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2155873 | Pathology - Research and Practice | 2012 | 4 Pages |
Abstract
A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q− after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q− and Philadelphia chromosome t(9;22)(q34:q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia.
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Authors
Vladimir Jurisic, Natasa Colovic, Tatjana Terzic, Vesna Djordjevic, Milica Colovic,