| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2156636 | Pathology - Research and Practice | 2008 | 5 Pages |
Abstract
The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC.
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Authors
Elena R.C. Rivero, Martinho C.R. Horta, Eliete N. Silva Guerra, Alberto R. Ferraz, Fábio D. Nunes,