Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2160260 | Radiotherapy and Oncology | 2008 | 4 Pages |
Abstract
This is the first study to demonstrate that the small-molecule Bcl-2 inhibitor HA14-1 renders human cervical cancer cells and their Bcl-2 overexpressing radioresistant counterparts, but not normal fibroblasts, more susceptible to heavy ions. Thus, Bcl-2 may be an attractive target for improving the efficacy of heavy-ion therapy.
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Authors
Nobuyuki Hamada, Keiko Kataoka, Sakura Sora, Takamitsu Hara, Motoko Omura-Minamisawa, Tomoo Funayama, Tetsuya Sakashita, Takashi Nakano, Yasuhiko Kobayashi,