| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2160496 | Radiotherapy and Oncology | 2007 | 5 Pages |
Abstract
The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT 213Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET.
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Authors
Stéphane Supiot, Francois Thillays, Emmanuel Rio, Sébastien Gouard, Alfred Morgenstern, Frank Bruchertseifer, Marc-André Mahé, Jean-François Chatal, François Davodeau, Michel Chérel,