| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2160642 | Radiotherapy and Oncology | 2008 | 5 Pages |
Abstract
The novel agent PRIMA-1met can reactivate WTp53 function in MTp53-expressing cells. We investigated PRIMA-1met as a radiosensitizer of WTp53, p53Null or MTp53 prostate cancer cells. Radiosensitization was observed in PC3 (p53Null) cells, even under hypoxia. In certain circumstances, PRIMA-1met may therefore act independently of MTp53 status and WTp53 transactivation.
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Authors
Stéphane Supiot, Helen Zhao, Klas Wiman, Richard P. Hill, Robert G. Bristow,