Solubility of erythromycin in ionic liquids

(Solid + liquid) and (liquid + liquid) phase equilibria of binary mixtures containing various ionic liquid and erythromycin were studied. The solubility of erythromycin in 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, or 1-decyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, or trihexiltertadecilphosphonium chloride, or butyltrimethylammonium bis(trifluoromethylsulfonyl)imide, or methyltrioctylammonium bis(trifluoromethylsulfonyl)imide, or 1-butyl-1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl)imide has been measured by a dynamic method, in a wide range of temperatures from (284 to 358) K, at atmospheric pressure. The activity coefficients of erythromycin in ionic liquids were calculated and their comparison with ideal solution was discussed. The experimental data were correlated successfully by means of the semi-empirical Grant equation.

► Solubility of erythromycin in various ionic liquids is slightly enhanced by temperature rise. ► Solubilities of erythromycin in ionic liquids are considerably higher than in common organic solvents. ► Nature of interactions between erythromycin and ionic liquids changes depending on temperature and composition.