Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
216439 | The Journal of Chemical Thermodynamics | 2010 | 10 Pages |
Values of density, ultrasonic speed, and viscosity of salbutamol sulphate (SBS) have been determined in aqueous methanol solutions at T = (303.15, 308.15, 313.15, and 318.15) K. The apparent molar volume Vφ , partial molar volume Vϕ0, molar expansivity E20, isobaric thermal expansion coefficient (α2), and second derivative of infinite dilution of partial molar volume with temperature ∂2Vϕ0/∂T2 are evaluated using density data. Isentropic compressibility βs, change in isothermal compressibility Δβs , relative change in isentropic compressibility (Δβs/βs0), apparent molar compressibility Kφ and partial molar compressibility Kϕ0 values are calculated by using data on density with ultrasonic speed. Viscosity B-coefficient, variation of B-coefficient with temperature, i.e.,dB/dT , free energy of activation per mole of solvent Δμ10∗ and solute Δμ20∗ are evaluated using viscosity data. The above parameters are used to interpret the solute–solute, solute–solvent interactions and structure making/breaking ability of the drug in the given aqueous methanol solution.