| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2165861 | Cell Calcium | 2016 | 5 Pages |
•hASCs are multipotent cells that can differentiate into many cell types.•hASCs have V1a receptors and respond to AVP during adipocyte differentiation.•AVP signaling increases intracellular Ca2+ via the Gq–PLC–IP3 pathway.•Both Ca2+ influx and release from the endoplasmic reticulum are the Ca2+ sources.•AVP inhibits adipogenesis.
Intracellular Ca2+ signals are essential for stem cell differentiation due to their ability to control signaling pathways involved in this process. Arginine vasopression (AVP) is a neurohypophyseal hormone that increases intracellular Ca2+ concentration during adipogenesis via V1a receptors, Gq-proteins and the PLC–IP3 pathway in human adipose-derived stromal/stem cells (hASCs). These Ca2+ signals originate through calcium release from pools within the endoplasmic reticulum and the extracellular space. AVP supplementation to the adipogenic media inhibits adipogenesis and key adipocyte marker genes. This review focuses on the intersection between AVP, Ca2+ signals and ASC differentiation.
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