Article ID Journal Published Year Pages File Type
2165894 Cell Calcium 2015 7 Pages PDF
Abstract

- Knockdown of the mitochondrial protein Opa1 evokes enhanced mitochondrial Ca2+ uptake.
- In humans defect of OPA1 gene induces autosomal dominant optic atrophy (ADOA).
- We studied mitochondrial Ca2+ metabolism in fibroblasts of ADOA patients.
- The symptoms of visual malfunction correlated with mitochondrial Ca2+ uptake.
- Enhanced mitochondrial Ca2+ uptake may contribute to the progress of the disease.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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