Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2165894 | Cell Calcium | 2015 | 7 Pages |
Abstract
- Knockdown of the mitochondrial protein Opa1 evokes enhanced mitochondrial Ca2+ uptake.
- In humans defect of OPA1 gene induces autosomal dominant optic atrophy (ADOA).
- We studied mitochondrial Ca2+ metabolism in fibroblasts of ADOA patients.
- The symptoms of visual malfunction correlated with mitochondrial Ca2+ uptake.
- Enhanced mitochondrial Ca2+ uptake may contribute to the progress of the disease.
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Authors
László Fülöp, Anikó Rajki, Erika Maka, Mária Judit Molnár, András Spät,