| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2165978 | Cell Calcium | 2015 | 12 Pages |
Abstract
- The Ca2+ response to NAADP activates TRPM4-mediated cation currents in HeLa cells.
- NAADP-evoked Ca2+ signals are impaired by disrupting acidic organelles.
- NAADP-evoked Ca2+ signals are hindered by blocking SERCA, RyRs and InsP3Rs.
- Disrupting Ca2+ uptake by acidic organelles prevents ER Ca2+ loading and vice versa.
- Pharmacological manipulation alone cannot reliably identify NAADP targets.
Keywords
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Authors
Virginia Ronco, Duilio Michele Potenza, Federico Denti, Sabrina Vullo, Giuseppe Gagliano, Marialuisa Tognolina, Germano Guerra, Paolo Pinton, Armando A. Genazzani, Lisa Mapelli, Dmitry Lim, Francesco Moccia,