| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2166182 | Cell Calcium | 2011 | 8 Pages |
Abstract
L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca2+ flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus. Specifically we highlight recent work demonstrating an auto-feedback regulatory pathway whereby the LTCC transcription factor regulates the LTCC. Also discussed is acute and long-term regulation of function by the LTCC-transcription regulator.
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Authors
Jonathan Satin, Elizabeth A. Schroder, Shawn M. Crump,