| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2166279 | Cell Calcium | 2010 | 7 Pages |
Abstract
Simultaneous recording of cytosolic and sarco-endoplasmic reticulum (SR/ER) luminal free calcium concentrations ([Ca2+]i and [Ca2+]L, respectively) supports the notion that release channels (RyRs and IP3Rs) use a concealed Ca2+ source, likely to be associated with intra-SR/ER Ca2+ binding proteins, whereas SR/ER Ca2+ leak channels can only access free luminal Ca2+. We hypothesize that Ca2+ is trapped by oligomers of luminal Ca2+-binding proteins and that the opening of release channels induces the rapid liberation of this “concealed” Ca2+ source associated with intra-ER Ca2+ buffers. Our hypothesis may also clarify why SERCA pumps potentiate Ca2+ release and explain quantal characteristics and refractory states of Ca2+ release process.
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Authors
Agustin Guerrero-Hernandez, Adan Dagnino-Acosta, Alexei Verkhratsky,