Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2166578 | Cell Calcium | 2007 | 11 Pages |
Abstract
Store-operated CRAC channels, which are activated by the emptying of the endoplasmic reticulum Ca2+ stores, are an important and widespread route for triggering rises in cytoplasmic Ca2+. The cellular responses that are activated in response to Ca2+ entry through CRAC channels are being dissected out, and recent evidence has established that CRAC channels can induce both short-term (safeguarding the Ca2+ content of the endoplasmic reticulum, maintenance of cytoplasmic Ca2+ oscillations, enzyme activation, secretion) and long-term (gene expression) changes in cells. CRAC channel activation is therefore capable of evoking a range of temporally distinct responses, highlighting the versatility of this ubiquitous Ca2+ entry pathway.
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Authors
Anant B. Parekh,