Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2166914 | Cellular Immunology | 2015 | 9 Pages |
Abstract
MAGEA10, a cancer/testis antigens expressed in tumors but not in normal tissues with the exception of testis and placenta, represents an attractive target for cancer immunotherapy. However, suppressive cytoenvironment and requirement of specific HLA-alleles presentation frequently led to immunotherapy failure. In this study MAGEA10 was scarcely expressed in cancer patients, but enhanced by viili polysaccharides, which indicates a possibility of increasing epitopes presentation. Furthermore the correlation of gene expression with methylation, indicated by R2 value for MAGEA10 that was 3 times higher than the value for other MAGE genes tested, provides an explanation of why MAGEA10 was highly inhibited, this is also seen by Kaplan-Meier analysis because MAGEA10 did not change the patients' lifespan. By using Molecular-Docking method, 3 MAGEA10 peptides were found binding to the groove position of HLA-Aâ0210 as same as MAGEA4 peptide co-crystallized with HLA-Aâ0210, which indicates that they could be promising for HLA-Aâ0201 presentation in immunotherapy.
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Authors
Likui Wang, Yuefang Xu, Cheng Luo, Jian Sun, Jinlu Zhang, Ming-Wei Lee, Aiping Bai, Guanhua Chen, Christopher M. Frenz, Zhengguo Li, Wenlin Huang,