| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2166985 | Cellular Immunology | 2014 | 7 Pages |
•Recombinant ERDR1 enhances NK cell cytotoxicity through the degranulation pathway.•Recombinant ERDR1 directly induces F-actin accumulation at the immunological synapse.•Vav-1 is strongly phosphorylated after recombinant ERDR1 treatment.•ERDR1 may have anti-cancer applications that involve the human immune system.
Erythroid differentiation regulator 1 (ERDR1), which is a stress-related survival factor, exhibits anti-cancer effects against melanoma. However, the function of ERDR1 on immune cells has not been examined. We investigated whether ERDR1 regulates the cytotoxic ability of human natural killer (NK) cells, which are known as innate effector lymphocytes. In this study, treatment with recombinant ERDR1 resulted in enhanced NK cell cytotoxicity through the secretion of lytic granules. Furthermore, actin modulation was involved in the ERDR1-enhanced NK cell cytotoxicity. ERDR1 stimulated actin accumulation at the immunological synapse, which was induced by the activation of Vav-1 in NK cells. These findings suggest new insight into the function of ERDR1 function in the human immune system.
