| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2167285 | Cellular Immunology | 2011 | 11 Pages |
Abstract
⺠New isoprenoid adjuvants developed for vaccines. ⺠They are chemically modified phytol derivatives, PHIS-01, PHIS-02, and PHIS-03. ⺠New adjuvants are safe and significantly augment specific immune response. ⺠PHIS-01 and PHIS-02 induce largely Th1 response, PHIS-03 induces Th2 response. ⺠They modulate immune system by apoptosis/necrosis.
Keywords
CDCo-phenylene diamineβ-CyDIFAPHISAPCKLHHRPADCCCTLCFAPBSLPSDMEMcomplete Freund’s adjuvantincomplete Freund’s adjuvantBSADMSOopdbovine serum albuminantibody-dependent cellular cytotoxicityantigen-presenting cellenzyme linked immunosorbant assayELISADimethyl sulfoxidephosphate buffer salinecytotoxic T lymphocytelipopolysaccharidecomplement dependent cytotoxicityHorseradish peroxidasekeyhole limpet hemocyanin
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Authors
Youssef Aachoui, Michael L. Schulte, Richard W. Fitch, Swapan K. Ghosh,