Antigen adsorbed calcium phosphate nanoparticles stimulate both innate and adaptive immune response in fish, Labeo rohita H.

Calcium phosphate nanoparticles as an antigen/protein delivery was explored in a fish model Labeo rohita H. S-layer protein (of Aeromonas hydrophila) adsorbed on nano sized calcium phosphate particles elicited both innate and adaptive immune parameters which persisted up to 63 days of post immunization through parenteral immunization and gave cross protections.

► S-layer protein adsorbed calcium phosphate nanoparticles stimulates both innate and adaptive immune response. ► With no toxic side effects. ► Gives cross protection against other Aeromonas hydrophila isolates.