Article ID Journal Published Year Pages File Type
2167294 Cellular Immunology 2011 6 Pages PDF
Abstract
► IL-1β-mediated induction of the COX2 gene requires p65 and p50. ► Genes encoding EP 1-4 receptors are expressed in rat islets and β-cell lines. ► COX2 and EP-4 gene expression is enhanced by PGD2 and PGE2. ► Expression of the EP-3 gene is decreased by PGD2 and PGE2. ► PGD2 and PGE2 augment cytokine-mediated NF-κB and GAS reporter gene activity.
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