Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2167302 | Cellular Immunology | 2011 | 5 Pages |
The expression of the programmed death 1 (PD-1) gene is an indicator of exhausted T-cells with decreased activation and function. It remains unknown, however, whether the methylation status of the PD-1 gene promoter is associated with PD-1 expression level. This study shows the changes of PD-1 expression levels and the demethylation status of the PD-1 promoter region in Molt-4 cells under different concentrations of 5-azacytidine (5-Zac). The result demonstrated that DNA demethylation at PD-1 promoter may contribute to PD-1 overexpression.
► 5-Azacytidine up-regulate cell surface receptor PD-1. ► DNA demethylation at PD-1 promoter may contribute to PD-1 overexpression. ► These are the first data showing alterations of PD-1 expression on lymphoid cell line by demethylation treatment.