| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2167319 | Cellular Immunology | 2011 | 8 Pages |
CD1c+ myeloid dendritic cells (mDCs) in the peripheral blood of 30 SHIV-SF162p4 and SIVmac251 sequentially infected Chinese rhesus macaques were examined by flow cytometry to obtain further insight into mDC alterations in HIV/AIDS. The CD1c+ cells were found to be mononuclear leukocytes rather than granulocytes, and most of them expressed CD20. CD1c+mDCs (CD1c+CD20−) consisted of two morphological subsets: the granular and the large CD1c+mDCs. The expression of HLA-DR, CD86, and CD11b, but no CCR7, CD83 and CD123, together with their endocytotic capacity indicated that they were immature mDCs. Their frequency at weeks 10 and 12 post-infection was significantly higher than that of un-infected ones; the large CD1c+mDC level was significantly different between time points and almost absent from un-infected rhesus monkeys; significant correlations between CD1c+mDCs and plasma viral load levels were also observed. These data indicated a possible role for CD1c+mDCs in the pathophysiological process of SIV/HIV infection.
► CD1c+ myeloid DCs in SHIV/SIV sequentially infected rhesus monkeys were examined. ► Two morphological subsets of CD1c+mDCs with immature phenotypes were found. ► The CD1c+mDC level at week 10-12 p.i. was higher than that of the uninfected monkeys. ► Significant correlations between CD1c+mDC and plasma viral load levels were observed.
