| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2167350 | Cellular Immunology | 2012 | 9 Pages |
Abstract
⺠Insulin expression in BM-derived thymic APCs is not essential for central tolerance of β-cells. ⺠Insulin expression in the spleen is restricted to Aire+CD11intB220+Gr1+ DCs. ⺠Insulin deletion in CD11c+ DCs induces increased insulitis in B6g7 mice. ⺠Peripheral insulin expression plays a role in maintaining β-cell tolerance.
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Authors
Maria Grupillo, Giulio Gualtierotti, Jing He, Giorgia Sisino, Rita Bottino, William A. Rudert, Massimo Trucco, Yong Fan,