Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2167501 | Cellular Immunology | 2011 | 11 Pages |
Abstract
CD8+ T-lymphocytes can utilize noncytolytic mechanisms to suppress HIV-1 replication through the secretion of soluble factors. The secretion of MIP-1β, MIP-1α, IP-10, MIG, IL-1α, and interferon gamma correlated most strongly with soluble noncytolytic suppression (p < 0.0001). Since the noncytolytic response is impaired by histone hyperacetylation, we examined the ability of histone hyperacetylation to alter the expression of immune-related genes. MIP-1α and IP-10 were also among the genes that were down-regulated by histone hyperacetylation. We define a multifactorial cytokine profile of CD8+ T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication.
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Authors
Kevin O. Saunders, Cavin Ward-Caviness, Robert J. Schutte, Stephanie A. Freel, R. Glenn Overman, Nathan M. Thielman, Coleen K. Cunningham, Thomas B. Kepler, Georgia D. Tomaras,