Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2168006 | Cellular Immunology | 2007 | 13 Pages |
Abstract
The inherent ability of the host immune system to distinguish between self- and non-self forms the basis of allorecognition. T lymphocytes constitute the most important effector arm of allorecognition. Here we describe the fundamentals of direct and indirect pathways by which allopeptides are presented to effector T cells. The nature of allopeptides presented along with tolerogenic strategies like altered peptide ligands and intra- or extra-thymic allopeptide inoculation are discussed. In addition, we speculate on the potential of regulatory T cells to modulate alloimmune responses.
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Authors
Ankit Bharat, T. Mohanakumar,