Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2168050 | Cellular Immunology | 2006 | 6 Pages |
Abstract
The role of histamine receptors in radiation-induced bone marrow (BM) regeneration was investigated with aspects of functional genomics. H1R and H2R mRNA expression increased during regeneration in both histidine decarboxylase knockout (HDC−/−) and wild type (HDC+/+) mice, though to a lesser extent in HDC−/− mice. H4R mRNA expression was downregulated in both groups. Mainly CD34+ cells were responsible for the elevation of intracellular histamine and HDC content in HDC+/+ BM cell populations. The differential changes in the expression of its receptors, and also its elevated levels in hematopoietic progenitors support the regulatory role of histamine in BM regeneration, that could be further explored by future gene expression studies.
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Authors
Zsuzsanna Horváth, Éva Pállinger, Győző Horváth, Ivett Jelinek, András Falus, Edit I. Buzás,